This PedsCases note provides a one-page overview on cleft lip and palate and its embryology, etiology, diagnosis, investigations, pathophysiology and management. It was created by Emma Yanko, a medical student at the University of Saskatchewan with the help of Dr. Craig Gendron, a pediatric plastic surgeon at the University of Saskatchewan. 

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Related Content: 

Podcast: Orofacial Clefts

References

1. Cleft lip and cleft palate - Symptoms and causes - Mayo Clinic [Internet]. Available from: https://www.mayoclinic.org/diseases-conditions/cleft-palate/symptoms-causes/syc-20370985

2. Janis, J.E. (Ed.). (2014). Essentials of Plastic Surgery (2nd ed.). CRC Press. https://doi.org/10.1201/b166101.

3. Leslie EJ, Marazita ML. Genetics of Cleft Lip and Cleft Palate. Am J Med Genet C Semin Med Genet. 2013;163(4):246-258. doi:10.1002/ajmg.c.31381

4. Nahai FR, Williams JK, Burstein FD, Martin J, Thomas J. The Management of Cleft Lip and Palate: Pathways for Treatment and Longitudinal Assessment. Semin Plast Surg. 2005;19(4):275-285. doi:10.1055/s-2005-925900

5. Shi M, Wehby GL, Murray JC. Review on Genetic Variants and Maternal Smoking in the Etiology of Oral Clefts and Other Birth Defects. Birth Defects Res C Embryo Today. 2008;84(1):16-29. doi:10.1002/bdrc.20117