Jeffrey, an 18-month-old child, presents to the emergency department with generalized edema. You walk into the exam room and elicit the following history:

Pt ID – Jeffrey, 18-month-old male

CC – Generalized swelling

HPI - Two days ago, Jeffrey’s father started noticing swelling around his eyes. The same day, Jeffrey’s mother noticed that his socks had left an imprint in his ankle. They think he may have gained some weight. He has been irritable over the past few days. His intake of food and water has been normal over the period, but his mother thinks he has been peeing much less frequently.

About one week ago, Jeffrey had a “cold”. This lasted for 3-4 days and he had a cough and a runny nose. He does not seem to get ill more often than his siblings.

Apart from the swelling, Jeffrey’s parents report that he has been completely healthy. There were no problems with the pregnancy or delivery. He has seen his family physician for regular checkups with no concerns about growth or development.

PMHx – Unremarkable. No surgeries.

FHx – Jeffrey’s father and grandfather have Type 2 diabetes.

Meds – None

Allergies- No known allergies

Immunizations – up to date

Renal disease is the most common cause of generalized edema in children. Assuming there is a renal cause to the edema, which is the most likely cause?